Possible Interaction: Aldosterone and Adrenocorticotropic Hormone

“Following injection of ACTH there were significant increases in cortisol (from 63 +/- 29 to 274 +/- 58 micrograms/l), aldosterone (from 86 +/- 37 to 300 +/- 105 ng/l) (both P < 0.001) and 11-desoxycortisol (from 5.3 +/- 1.2 to 9.8 +/- 4.6 micrograms/l; P < 0.05).”

“The enhanced response of plasma aldosterone may in part be related to the concurrent rises in ACTH , but a similar sustained aldosterone response was observed in subjects without ACTH release.”

“The renin‐angiotensin system, ACTH and hyperkalaemia are known to induce increased plasma levels of aldosterone.”

“Angiotensin II, in a pressor dose given by constant infusion for 1 hr, increased plasma aldosterone to 28.5 ±5 (sd) ng/100 ml, while ACTH had a significantly greater effect, increasing aldosterone to 64 ±10 mean ±(sd) ng/100 ml.”

“With cessation of adrenocorticotropin, aldosterone fell to <50% of control values and remained reduced for 5–7 days.”

“We highlight the mechanisms explaining the differential acute vs chronic effects of ACTH on aldosterone and glucocorticoid secretion.”

“ ACTH was a strong secretagogue for aldosterone , causing a 3-8-fold increase in concentration.”

“ ACTH , particularly in the presence of LDL, stimulated secretion by glomerulosa cells of Aldo and 18-OH B, as well as that of F, And, and 11 beta-OH And.”

“ ACTH increased basal aldosterone production, and the addition of either lipoprotein fraction further enhanced ACTH-induced aldosterone production.”

“ ACTH , AII and ASF induced dose-related increases in both aldosterone and cortisol production.”