“Growth of subcutaneous implants of RENCA renal carcinoma was also inhibited by the combination of IL-2 and M40403.”
“These results established that M40403 prevented IL-2 from causing dose-limiting hypotension, while enhancing its anticancer activity.”
“We have shown here that M40403 , a superoxide dismutase (SOD) mimetic, blocked IL-2-induced hypotension and allowed the dose of IL-2 to be increased in mice.”