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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Aldesleukin
supplement:
Garlic
Research Papers that Mention the Interaction
“Monocyte IL-10 production increased significantly and monocyte tumor necrosis factor-alpha (TNF-alpha), IL-1alpha, IL-6, IL-8, T-cell interferon-gamma (IFN-gamma), IL-2 , and TNF-alpha decreased significantly in the presence of >or=10 microg/ml garlic extract.”
Allium sativum (garlic) suppresses leukocyte inflammatory cytokine production in vitro: potential therapeutic use in the treatment of inflammatory bowel disease.“ Garlic is reported to stimulate immunity, including macrophage activity, natural killer and killer cells, and LAK cells, and to increase the production of IL-2 , TNF, and interferon-gamma.”
“The addition of IL-2 almost completely abolished inhibition of lymphocyte proliferation in the presence of higher concentrations of GAE.”
“The inhibitory effect of GAE correlated with a decrease in IL-2 production, but was not followed by down-regulation of IL-2Ralpha expression.”
Modulatory effects of garlic extracts on proliferation of T-lymphocytes in vitro stimulated with concanavalin A.“This effect may be related to the following factors that garlic can improve the activation of NK cells, the function of T-lymphocytes, and the level of IL-2.”
“Consequently, AGE stimulated the proliferation of mouse spleen cells and the release of cytokines, such as IL-2 , TNF-alpha and IFN-gamma, increased NK activities, and enhanced phagocytosis of peritoneal macrophages.”
Immunomodulation and antitumor activities of Aged Garlic Extract.
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