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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Aldesleukin
supplement:
Eicosatrienoic Acid
Research Papers that Mention the Interaction
“ DGLA suppresses T cell activation and production of interleukin-2 (IL-2).”
Effects of unsaturated fatty acids on expression of early response genes in human T lymphocytes.“Cis-unsaturated fatty acids such as dihomogamma-linolenic acid DGLA ), arachidonic acid (AA) and eicosapentaenoic acid (EPA), which form precursors to 1, 2 and 3 series prostaglandins (PGs), have been shown to suppress human T-cell growth in vitro by a prostaglandin E (PGE)-independent mechanism.”
“ DGLA and AA inhibited IL-2 production in a dose-dependent manner: half-maximal inhibition was obtained by using the fatty acids at the dose of 10 micrograms/ml without significant effects on cell viability.”
“Time course experiments showed that DGLA and AA inhibited IL-2 production even at times of minimal or no PGE release by the treated cultures.”
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