Possible Interaction: Aldesleukin and Calcium Supplement

“An increase in intracellular levels of calcium ions (Ca2+) results from the engagement of immunoreceptors, such as the T-cell receptor, B-cell receptor and Fc receptors, as well as chemokine and co-stimulatory receptors.”

“In multivariate regression, the highest tertiles of anti-HSP60 and IL-2 were associated with increased risk of CAC (HSP60 T3: OR 1.49, p=0.022; IL-2: OR 2.49, p<0.001).”

“Our data indicate that differences in the efficiency of costimulation are linked to differences in Ca2+ entry.”

“Studies from the author's laboratory have shown decreased Ca2+i mobilization and tyrosine phosphorylation correlated with suppressed T-cell IL-2 production and proliferation.”

“The IC50 for ChTX-inhibition of IL-2 elaboration and IL-2 mRNA were both 1 nM. Similarly, high [K+]e inhibited proliferation … +/- 1.2 mM (n = 6), and decreased IL-2 mRNA steady-state levels with an IC50 of 18 mM. The sensitivities of both IL-2 … calcium, ….”

“The mechanism of inhibition of IL2-stimulated enhancement of target cell killing is not yet known, however, the results are consistent with impairment of IL2 signalling, by CA.”

“This suggests that some stimulating factor may trigger transmission of calcium , which may be ejected directly from single stimulated cells and mediated via a membrane receptor but not through a gap junction.”

“In the present study, we investigated whether rhIL‐1 could also enhance the renal tubular reabsorption of calcium.”

“The calculated index of the tubular reabsorption of calcium (TRCal) was significantly increased by rhIL‐1 (2.18 ± 0.14 versus 1.79 ± 0.07 mmol/l GFR, p < 0.05, in vehicle‐treated rats).”

“The addition of interleukin 2 to IL-2 dependent cells caused an increase in the intracellular concentration of calcium ions , as measured using Quin 2.”