Possible Interaction: Aldesleukin and Adrenocorticotropic Hormone

“Single administration of the cytokine interleukin‐1α (IL‐1), or the psychostimulant amphetamine, enhanced adrenocorticotropin hormone and corticosterone responses to a stress challenge weeks later.”

“Rat interleukin-2 affected plasma adrenocorticotropin in a much slower manner and increased its levels significantly 120 min after the injection.”

“After intravenous injection of IL2 , a marked increase in ACTH levels occurred, peaking at 4 hour with a comparable peak in cortisol level at 5 hour.”

“Dose of 100 U IL-2 induced a profound increase of ACTH release.”

“An effect of treatment course was noted, … stimulated values seen 4 h after IL-2 in the second treatment course compared with those after the first … [change (delta) in beta-endorphin, 101 vs. 11 fmol/mL; delta ACTH , 138 vs. 8 pmol/L; delta …, 414 vs. 218 nmol/L].”

“At T51, treatment with ACTH caused down-regulation (P<0.001) of genes involved in "immune response" (IFNG and IL2 ) and up-regulation (P<0.001) of NF-κB1 and TP53.”

“These results demonstrated that ACTH modulates IL-2 secretion from activated lymphocytes, which is both biphasic and concentration dependent.”

“The combination of intraperitoneal injection of corticotropin and intra-hippocampal injection of IL-2 increased the number of SP-LI neurons in PAG furtherly as compared with IL-2 240 U alone (13.6 +/- 3.6 vs 7.6 +/- 4.3, P < 0.05).”

“There is a synergetic relation between IL-2 and corticotropin.”

“ Interleukin-2 (IL-2) has been shown to stimulate ACTH secretion by anterior pituitary cells and has been implicated in pathophysiological processes of the pituitary and brain in several major neuropsychiatric disorders.”

“ IL-2 induced increases in plasma levels of adreno-corticotropic hormone (ACTH, up to two-fold) and corticosterone (up to four-fold) compared with controls.”