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Discover Supplement-Drug Interactions

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Last Updated: 5 months ago

Possible Interaction: Alcohols and Fomepizole



Research Papers that Mention the Interaction

Pretreatment with 4-methylpyrazole , a specific inhibitor of alcohol dehydrogenase, led to a significant decrease in the cutaneous vascular response to the alcohols as a group, but did not lead to changes in the cutaneous vascular response to the aldehydes as a group.
The Journal of investigative dermatology  •  1988  |  View Paper
The data showed that ethanol and 4-MP , the main antidotes in methanol or ethylene glycol poisoning, may increase liver LDH activity - an undesirable effect during the therapy of patients intoxicated with these alcohols.
Journal of applied toxicology : JAT  •  2005  |  View Paper
The rates of elimination of various alcohols were inhibited on average 73% (55% for 2-propanol to 90% for ethanol) by 1 mmol/kg of 4-methylpyrazole , a good inhibitor of ADH, indicating a major role for ADH in the metabolism of the alcohols.
Chemico-biological interactions  •  2015  |  View Paper
In vitro, 4-methylpyrazole was shown to inhibit microsomal oxidation of drugs and alcohols.
Biochemical and biophysical research communications  •  1985  |  View Paper
Time course experiments and dose-response experiments … an increase in the microsomal oxidation of alcohols could be observed 24 hr after a single treatment … mg/kg body weight of either pyrazole or 4-methylpyrazole , and after 2 or 3 days of treatment … mg/kg of either of these compounds.
Alcoholism, clinical and experimental research  •  1985  |  View Paper