Possible Interaction: Alcohols and Fomepizole

“Pretreatment with 4-methylpyrazole , a specific inhibitor of alcohol dehydrogenase, led to a significant decrease in the cutaneous vascular response to the alcohols as a group, but did not lead to changes in the cutaneous vascular response to the aldehydes as a group.”

“ 4-Methylpyrazole (4-MP, an inhibitor of alcohol dehydrogenase, ADH) at a dose of 7 mg/kg body weight inhibited ethanol elimination by 29% in nonalcoholic controls and by 35% in alcoholics with adequate nutrition, but only by 19% in alcoholics with inadequate nutrition.”

“The rates of elimination of various alcohols were inhibited on average 73% (55% for 2-propanol to 90% for ethanol) by 1 mmol/kg of 4-methylpyrazole , a good inhibitor of ADH, indicating a major role for ADH in the metabolism of the alcohols.”

“In vitro, 4-methylpyrazole was shown to inhibit microsomal oxidation of drugs and alcohols.”

“By contrast, the 4-methylpyrazole treatment , besides increasing the oxidation of alcohols , also increased the oxidation of aminopyrine and the content of cytochrome P-450.”

“Time course experiments and dose-response experiments … an increase in the microsomal oxidation of alcohols could be observed 24 hr after a single treatment … mg/kg body weight of either pyrazole or 4-methylpyrazole , and after 2 or 3 days of treatment … mg/kg of either of these compounds.”