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Last Updated: 7 months ago

Possible Interaction: Alcohols and Fomepizole

supplement:

Alcohols

Research Papers that Mention the Interaction

Pretreatment with 4-methylpyrazole , a specific inhibitor of alcohol dehydrogenase, led to a significant decrease in the cutaneous vascular response to the alcohols as a group, but did not lead to changes in the cutaneous vascular response to the aldehydes as a group.
The Journal of investigative dermatology  •  1988  |  View Paper
4-Methylpyrazole (4-MP, an inhibitor of alcohol dehydrogenase, ADH) at a dose of 7 mg/kg body weight inhibited ethanol elimination by 29% in nonalcoholic controls and by 35% in alcoholics with adequate nutrition, but only by 19% in alcoholics with inadequate nutrition.
Metabolism: clinical and experimental  •  1978  |  View Paper
The rates of elimination of various alcohols were inhibited on average 73% (55% for 2-propanol to 90% for ethanol) by 1 mmol/kg of 4-methylpyrazole , a good inhibitor of ADH, indicating a major role for ADH in the metabolism of the alcohols.
Chemico-biological interactions  •  2015  |  View Paper
In vitro, 4-methylpyrazole was shown to inhibit microsomal oxidation of drugs and alcohols.
Biochemical and biophysical research communications  •  1985  |  View Paper
By contrast, the 4-methylpyrazole treatment , besides increasing the oxidation of alcohols , also increased the oxidation of aminopyrine and the content of cytochrome P-450.
Time course experiments and dose-response experiments … an increase in the microsomal oxidation of alcohols could be observed 24 hr after a single treatment … mg/kg body weight of either pyrazole or 4-methylpyrazole , and after 2 or 3 days of treatment … mg/kg of either of these compounds.
Alcoholism, clinical and experimental research  •  1985  |  View Paper