Possible Interaction: Albuterol and Potassium

“Within 3 min after inhalation of salbutamol, potassium levels declined as a function of time.”

“Several studies have reported a decrease in plasma potassium levels in uremic patients treated with salbutamol , a ß2-adrenergic agonist [3-5].”

“The potassium fall, present in all groups, was more pronounced in the groups treated with high doses of albuterol.”

“ Salbutamol decreased … potassium concentrations from 4.5 +/- 0.1 to 3.8 +/- 0.1 mmol l-1 in the CF group (P < 0.05) and from 4.1 +/- 0.2 to 3.4 +/- 0.1 mmol l-1 in the controls (P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)”

“CONCLUSIONS Both routes of administration of sa butamol re sulted in a prompt and significant decrease of plasma pot assium co ncentrations and both are considered as simple, effective and safe alternatives in treating hyperkalemia in patients with CRF.”

“Mean (+/- SEM) potassium fell to a lower level with bendrofluazide and albuterol in women than in men (2.45 +/- 0.04 mmol/L versus 2.90 +/- 0.13 mmol/L; p less than 0.005).”

“Administration of the beta2 adrenergic agonists fenoterol, salbutamol and terbutaline to volunteers significantly reduced plasma potassium concentration in a double-blind crossover study.”

“CONCLUSION Nebulized al uterol in creases lactate levels and decreases pot assium le vels in healthy adults.”

“Compared to the injection of saline, salbutamol caused a decrease in the serum digoxin and potassium concentrations.”

“A slight but significant decrease was observed in the plasma potassium level up to 125 min after the salbutamol infusion.”