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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Albuterol
supplement:
Epinephrine
Research Papers that Mention the Interaction
“There was an increased heart rate after both adrenaline and salbutamol and ventricular ectopic beats and a short run of parasystole were recorded on the ECG in one patient after adrenaline and in two patients after salbutamol.”
“We conclude that both adrenaline and a selective beta 2 agonist salbutamol can cause a fall in SaO2 and ventricular ectopy in some asthmatic patients.”
Comparison of the effect of inhaled selective and non-selective adrenergic agonists on cardiorespiratory parameters in chronic stable asthma.“ Salbutamol was less potent in vitro producing a mean (SE) 2.4 (0.15) doubling dose increase in the histamine EC20 and adrenaline a 5.2 (0.18) doubling dose increase (mean difference between salbutamol and adrenaline 2.8 doubling doses; 95% CI 1.1 to 4.5).”
“The intrinsic efficacy of salbutamol is only 5 % that of adrenaline , meaning that when linked to the same number of receptors, adrenaline produces a 20-fold higher activation of β2 adrenoceptors [7, 8].”
“When adjusted for severity of illness, patients who received albuterol were significantly more likely than patients receiving epinephrine to be successfully discharged (aRR = 1.18, 95% CI = 1.02 to 1.36).”
“There is some evidence to suggest that epinephrine may be favourable to salbutamol and placebo among outpatients.”
“Repeated exposure to norepinephrine or salbutamol suppressed both the glucagon and epinephrine responses to hypoglycemia compared to controls.”
Repeated Activation of Noradrenergic Receptors in the Ventromedial Hypothalamus Suppresses the Response to Hypoglycemia.“… epinephrine increased the UCP3 mRNA level transiently at 6 h, and also the UCP2 mRNA level at 6-24 h. … were also observed in the presence of carbacyclin and 9-cis retinoic acid, and mimicked by isoproterenol and salbutamol (beta2-AR agonists), but abolished …-118,551 (beta2-AR antagonists).”
“Atenolol, 10(-6) M, and butoxamine, 3 X 10(-8) M, beta-1 and beta-2 antagonists, respectively, … 10(-8) M. Tazolol, 3 X 10(-7) and 10(-6) M, a beta-1 agonist, and salbutamol , 10(-8) and 3 X 10(-… dependently increased the evoked release of epinephrine.”
“After epinephrine and salbutamol a similar significant decrease in airflow obstruction was associated with only slightly more V/Q mismatching than after saline.”
“Findings Mean hospitalization duration was 3.3±1.1 and 3±0.9 in the patients receiving salbutamol and epinephrine , respectively (P=0.03).”
Comparison of Epinephrine to Salbutamol in Acute Bronchiolitis
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