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Last Updated: 2 years ago

Possible Interaction: Albumin and Valproic Acid

supplement:

Albumin

Research Papers that Mention the Interaction

A critical property of valproate is its high binding of about 90% to plasma proteins, primarily albumin.
Therapeutic drug monitoring  •  2006  |  View Paper
Use of 5% albumin dialysate further increased VPA and CBZ clearance.
We investigated whether the addition of albumin to dialysate affects dialytic clearance of VPA , CBZ and PHT.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association  •  2009  |  View Paper
Administrations of D,L-carnitine and albumin reduced VPA hepatotoxicity.
Neuropediatrics  •  1988  |  View Paper
Our hypothesis is that the low albumin level was associated with high plasma clearance of valproic acid , leading to extremely low total drug concentrations.
The Annals of pharmacotherapy  •  2011  |  View Paper
The free fraction of valproate varied six to seven-fold as albumin concentration ranged from 1.5 to 4.8 g 100 ml-1 (218-696 mumol l-1).
British journal of clinical pharmacology  •  1994  |  View Paper
Furthermore, the introduction of a double bond into the carbon backbone of valproate increases affinity for albumin at both sites.
Biochemical pharmacology  •  1991  |  View Paper
There was a highly significant negative correlation between free VPA fractions and fetal albumin concentrations.
Journal of clinical pharmacology  •  1986  |  View Paper
Valproate is bound to two sites on the albumin molecule, the diazepam and warfarin sites, with the association constants, Ka, 3.1 x 104 M-1.
Molecular pharmacology  •  1980  |  View Paper
The spectra exhibited a strong decrease of the valproate signal with increasing albumin concentration.
Neuroradiology  •  2004  |  View Paper