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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Albumin
drug:
Valproic Acid
Research Papers that Mention the Interaction
“A critical property of valproate is its high binding of about 90% to plasma proteins, primarily albumin.”
Measuring unbound versus total valproate concentrations for therapeutic drug monitoring.“Use of 5% albumin dialysate further increased VPA and CBZ clearance.”
“We investigated whether the addition of albumin to dialysate affects dialytic clearance of VPA , CBZ and PHT.”
“Administrations of D,L-carnitine and albumin reduced VPA hepatotoxicity.”
“Our hypothesis is that the low albumin level was associated with high plasma clearance of valproic acid , leading to extremely low total drug concentrations.”
“The free fraction of valproate varied six to seven-fold as albumin concentration ranged from 1.5 to 4.8 g 100 ml-1 (218-696 mumol l-1).”
“Furthermore, the introduction of a double bond into the carbon backbone of valproate increases affinity for albumin at both sites.”
“There was a highly significant negative correlation between free VPA fractions and fetal albumin concentrations.”
“ Valproate is bound to two sites on the albumin molecule, the diazepam and warfarin sites, with the association constants, Ka, 3.1 x 104 M-1.”
“The spectra exhibited a strong decrease of the valproate signal with increasing albumin concentration.”
In vivo 1H magnetic resonance spectroscopy of rat brain after valproate administration
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