Possible Interaction: Albumin and Urea

“However, under unfolding conditions, the lifetime of albumin experienced gradual decrease with the increase of the urea concentration from initial 6.3 ns to 4.0 ±0.14 ns in 6M urea solution.”

“We aimed at partial denaturation of the albumin with urea.”

“ Urea can promote the carbamylation of proteins on multiple lysine side chains, including human albumin , which has a predominant carbamylation site on Lys549.”

“ Albumin dimerisation in nephrotic urine frozen to -20 degrees C occurs at low ionic strength in the presence of quite low concentrations of urea (greater than 0.2 mol/l).”

“The rate of urea nitrogen incorporation into albumin increased on average 14-fold in chronic renal failure.”

“A significant negative correlation was noted between efficiency of urea nitrogen utilization and the rate of synthesis of albumin.”

“Also, Sa significantly decreased plasma total protein (TP), albumin Alb ) and high density lipoprotein-cholesterol (HDL-c), while increased glucose, urea , creatinine, bilirubin, total lipid (TL), cholesterol, triglyceride (TG) and low density lipoprotein-cholesterol (LDL-c).”

“The higher virial osmotic coefficients of egg albumin in various electrolytes and in 1 m urea as well as a function of NaCl concentration are reported.”

“It is deduced that approximately 1 molecule of urea or thiourea interacts per 3 or 4 amino acid residues of each fully denatured albumin molecule.”

“When bovine mercaptalbumin is dissolved in concentrated urea solutions, light-scattering studies indicate that the albumin molecule is considerably swollen by selective binding of the urea from the mixed solvent.”