Possible Interaction: Albumin and Tryptophan

“Conclusions: Abnormal kinetics of L-Trp binding to albumin explains the increased availability of this precursor amino acid in the plasma of IUGR infants.”

“The plasma ratio of tryptophan to other LNAA decreased by 30 to 50%, and at 4 hours the plasma tryptophan ratio was still significantly below control level after the 2 larger albumin doses.”

“This substitution leads to a 20-fold increase in affinity of albumin for T4 binding to the 2A region of the protein, a region which also binds tryptophan , bilirubin and a number of drugs and other ligands.”

“Besides there is appearance of a positive correlation between albumins and bound tryptophan and a negative correlation between albumins and free tryptophan.”

“It is suggested that the availability of the binding sites for L-tryptophan , warfarin and salicylic acid is partially blocked by the complex between albumin and the dye without direct participation in the complex-formation.”

“ L-Tryptophan and diazepam were found to compete for a common high-affinity binding site on albumin.”

“It is known (Curzon et al., 1974; Kragh-Hansen, 1983) that this binding of Trp to albumin is affected by various substances such as free fatty acids (FFA).”

“ Tryptophan limitation caused a decrease in albumin nuclear transcript abundance, and this decrease preceded the decrease in albumin mRNA, suggesting that the decrease in albumin mRNA was caused at least partly by a decrease in albumin gene transcription.”

“… albumin concentration up to 2 g/… reduced the BUI of L‐tryptophan , but a further increase in albumin concentration up to 9 g/100 ml respited in only a slow fall … of L‐tryptophan which was not proportional to the larger fall in the concentration of unbound L‐tryptophan.”

“A rapid rate of dissociation of tryptophan from albumin (compared to the transit time of tryptophan through the liver) and a large fractional extraction of the free pool of tryptophan during passage through the liver are shown to be necessary factors in determining the effects observed.”