Possible Interaction: Albumin and Triiodothyronine

“ T3 recovery in the presence of 1 mg/mL of albumin was 107±2% (mean±standard error of the mean) of anticipated drug concentrations.”

“ Albumin (p < 0.01) and transferrin levels (p < 0.05) were significantly increased from T0 to T3.”

“We wish to report a family in which there is increased binding of T3 to TBG, TBPA and albumin.”

“Upon analyzing the binding parameters, albumin decreased with age and correlated closely with the age dependent T3 parameters (TT3: r = 0.6610, apparent FT3 by analog: r = 0.7664; both p < 0.001).”

“Nonesterified fatty acids (NEFA) and the T3 analog apparently bind to different sites on albumin ; thus the Amerlex FT3 assay is insensitive to moderately increased concentrations of NEFA in serum.”

“The affinity constant for T3 binding to the albumin was substantially raised (2·2 × 105 l/mole; normal immeasurable), that for rT3 (1·4 × 106 l/mole) was five‐fold greater than normal, and that for T4 (6±× 105 l/mole) was increased three‐fold.”

“ Iodothyronine uptake in uninjected oocytes was reduced by albumin , but the stimulation induced by MCT8 was markedly increased.”

“Exposure of embryos to 10(-8) M T3 , which regulates amphibian metamorphosis, resulted in the premature induction of albumin mRNA, such that it is evident by stage 43.”

“ Triiodothyronine caused a sevenfold increase in translatable albumin mRNA and a threefold increase in translatable mRNA for the 23,000 dalton protein.”

“Bovine albumin also inhibited blood-brain barrier transport of T3).”

“The apparent dissociation constant (Kd) of albumin binding of T3 at the brain capillary level (76 μM) was 16-fold greater than the K3 of albumin binding of T3 in vitro (4.7 μM), as determined by equilibrium ...”

“The fractional inhibition of T3 transport by albumin was a measure of the binding of T3 by albumin in vivo, i.e. in the presence of a competing binding system, the BBB T3 carrier.”