Possible Interaction: Albumin and Tretinoin

“It was demonstrated that the administration of exogenous RA isomers retinoids ) can bypass the activity of albumins enhancing the regeneration of podocytes.”

“R‐III treatment and albumin expression downregulated retinoic acid (RA) signaling which was involved in HSC activation.”

“In particular, regeneration is severely impaired by proteinuria, when albumin sequesters retinoic acid and blocks RPC differentiation in podocytes.”

“In particular, albumin prevented podocyte differentiation from human renal progenitors in vitro by sequestering retinoic acid , thus impairing retinoic acid response element (RARE)-mediated transcription of podocyte-specific genes.”

“These results suggest that albumin loss through the damaged filtration barrier impairs podocyte regeneration by sequestering retinoic acid and promotes the generation of FSGS lesions.”

“ Albumin mRNA expression levels were increased by all‑trans retinoic acid and insulin‑transferrin‑selenium supplementation in WE medium compared with cells cultured in ReproFF.”

“The present studies show that the proliferation inhibition and albumin secretion of hepatoma carcinoma cells are enhanced with all-trans retinoic acid (ATRA) encapsulated in the nanoparticles.”

“Recent evidence suggests that retinoids act on renal progenitors by promoting their differentiation into mature podocytes and retinoic acid-induced podocyte differentiation is impaired by proteinuria because of sequestration of retinoic acid by albumin.”

“In the present study, deletion … luciferase assays demonstrate that ATRA causes a marked decrease … activity of the albumin promoter, the region between nt -367 and -167 from the transcription start site, where C/EBP (…/enhancer-binding protein)-binding sites are tightly packed, is indispensable for ATRA-mediated down-regulation.”

“In DMS-treated cells, 9-cis retinoic acid RA ) further enhanced HNF-4alpha and albumin expression but it inhibited AFP accumulation.”

“Synthesis of albumin was slightly inhibited by IL-6 and RA , and synthesis of transferrin was increased by RA but not by IL-6.”