Possible Interaction: Albumin and Tissue Plasminogen Activator

“Whole-blood dilution by 15% with crystalloids and albumin in the presence of tissue factor plus tPA resulted in an abnormal TEG pattern and increased fibrinolysis, as did dilution with synthetic colloids.”

“The tPA-treated subjects who received higher-dose ALB were three times more likely to achieve a good outcome than subjects receiving lower-dose ALB, suggesting a positive synergistic effect between ALB and tPA.”

“Furthermore, t-PA antigen and albumin plasma levels were negatively correlated (r = 0.48; p = 0.0015) and t-PA antigen and bilirubin were positively correlated (r = 0.46; p = 0.0022) thus indicating that the liver is mainly involved in the clearance of t-PA antigen.”

“Combination therapy using tPA with albumin also improved neurological deficits and reduced brain edema significantly (p<0.05).”

“Conclusion: In acute ischemic stroke, combination therapy using tPA with albumin can attenuate the deleterious effects of tPA.”

“However, whether albumin can attenuate the deleterious effects of tPA is yet unknown.”

“Relative to tPA-treated group, rats that received combination therapy using tPA with albumin had significantly reduced blood–brain barrier permeability, evaluated by quantitation of Evans blue leakage (p<0.05).”

“The infarct volume in rats that received tPA with albumin was significantly decreased to 29.2 ± 3.3% (p<0.05), compared with tPA-only-treated group.”

“Denatured preparations of apoferritin, antithrombin, alpha1-protease inhibitor, alpha2-macroglobulin, and albumin also accelerate des(1-77)-plasminogen activation by tPA.”