Possible Interaction: Albumin and Thyroxine

“ Albumin , with the lowest T4 affinity and fastest T4 release of the major T4-binding proteins may promote quick exchange of T4 with tissue sites.”

“ Rat albumin (ka = 6.1 +/- 1.6 x …)M-1, at 37 C) bound T4 significantly more strongly than did rabbit albumin (ka = 2.3 +/- 0.4 x 10(5)M-1, … 37 C) when it was assumed that there was only one T4 binding site/molecule of albumin.”

“Inhibitors of T4 and T4 analog binding to the albumin included in the incubation buffer have been suggested to play a role for both the 1- and 2-step designs.”

“It is caused by mutations in the ALB (albumin) gene that increase the affinity of albumin for T4 by approximately 60-fold.”

“FDH is inherited in an autosomal dominant manner and is characterized by enhanced binding of thyroxine to a mutant form of albumin , probably at Site 1, subdomain 11A.”

“High density lipoproteins (HDL), albumin (HSA), transthyretin (TTR), and thyroxine-binding globulin (TBG) interfere with, rather than facilitate, T4 entry.”

“The effect on albumin synthesis may be mediated, at least in part, by a suppression of insulin-like growth factor-I, free thyroxine and tri-iodothyronine.”

“By heating at 58 degrees C, T4 bound to TBPA was denatured, but T4 bound to albumin showed a significant increase, and serum free T4 concentrations were increased to 396.0 +/- 62.1%.”

“The binding of thyroxine to both albumins effectively quenches the tryptophan emission probably via a nonradiative energy transfer mechanism.”

“These high serum thyroxine levels are traceable to altered binding of thyroxine to the patient's albumin.”

“Familial dysalbuminemic hyperthyroxinemia, a syndrome involving an abnormal affinity of albumin for thyroxine , results in elevated total thyroxine and free thyroxine index levels but normal triiodothyronine resin uptake and thyroid-stimulating hormone levels.”