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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Albumin
drug:
Sulfisoxazole
Research Papers that Mention the Interaction
“There was a statistically significant negative correlation between albumin concentration and the free fraction values of salicylic acid and sulfisoxazole (but not of phenytoin and only under special circumstances with warfarin) in normal subjects and of phenytoin, salicylic acid, and sulfisoxazole (but not warfarin) in rats.”
Intraindividual relationships between serum protein binding of drugs in normal human subjects, patients with impaired renal function, and rats.“ Sulfisoxazole … albumin concentration for bilirubin binding in pooled cord serum as estimated by rate of dialysis of 14C-monoacetyl-diamino-diphenylsulfone (MADDS) in undiluted serum at … 0.5 also showed that both drugs were capable of displacing bilirubin in vitro when added in molar excess of the albumin present.”
“By using equilibrium dialysis experiments, it is shown that sulfisoxazole binds extensively with albumin and alpha-globulin and to a lesser extent with gamma-globulin and lysozyme, all of which are normal components of tears.”
“This effect was most pronounced with the compounds which had the highest degree of protein binding, such as cloxacillin, cephazolin, methacycline and sulfisoxazole , all of which are bound greater than 80% by albumin.”
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