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Last Updated: 2 years ago

Possible Interaction: Albumin and Sulfisoxazole

supplement:

Albumin

Research Papers that Mention the Interaction

There was a statistically significant negative correlation between albumin concentration and the free fraction values of salicylic acid and sulfisoxazole (but not of phenytoin and only under special circumstances with warfarin) in normal subjects and of phenytoin, salicylic acid, and sulfisoxazole (but not warfarin) in rats.
Journal of pharmaceutical sciences  •  1977  |  View Paper
Sulfisoxazole … albumin concentration for bilirubin binding in pooled cord serum as estimated by rate of dialysis of 14C-monoacetyl-diamino-diphenylsulfone (MADDS) in undiluted serum at … 0.5 also showed that both drugs were capable of displacing bilirubin in vitro when added in molar excess of the albumin present.
Developmental pharmacology and therapeutics  •  1983  |  View Paper
By using equilibrium dialysis experiments, it is shown that sulfisoxazole binds extensively with albumin and alpha-globulin and to a lesser extent with gamma-globulin and lysozyme, all of which are normal components of tears.
Journal of pharmaceutical sciences  •  1976  |  View Paper
This effect was most pronounced with the compounds which had the highest degree of protein binding, such as cloxacillin, cephazolin, methacycline and sulfisoxazole , all of which are bound greater than 80% by albumin.
Pharmacology  •  1976  |  View Paper