Possible Interaction: Albumin and Steroids

“Strong interactions with albumins suppress the biological activity of steroids.”

“ Albumin regulated access of steroids to their receptors, as well as protecting animals from endocrine disruptors, such as phytochemicals, fungal chemicals and phenolics, and other chemicals formed at hydrothermal vents by geochemical processes.”

“In a multivariate analysis use of oral steroids in the three months prior to admission, erythrocyte sedimentation rate>70 mm/hr and albumin<2.5 g/dL were significantly associated with 5-year colectomy risk.”

“Also a variation was observed in amide I region indicating the formation of hydrogen bonding between albumin and steroids.”

“We report the case of a patient with DM where steroid administration may have caused a decrease in plasma GA and GA:HbA1c levels via increased albumin turnover.”

“Although no adverse clinical effects have been attributed to bisalbumins, some albumin variants have altered affinity for steroid hormones, thyroxine, or drugs.”

“These results demonstrate that albumin plays a central role in maintaining the concentration gradient of steroids between the preovulatory FF and the circulation.”

“We observed that late and dual, but not early, asthmatic reactions are associated with a transient increase of bronchial responsiveness which … reaction of the airways characterized by an increase of neutrophils followed by eosinophils, by an increase of leukotriene B4 and albumin in bronchoalveolar lavage … are inhibited by steroids.”

“Foetal steroid binding protein (FSBP) is a normal constituent of adult human serum; in vivo it appears to influence the degree of steroid binding to albumin rather than acting primarily as a high affinity saturable binding protein.”

“ Albumin synthesis rates were elvated in one patients treated with steroids and in one patient with very active arthritis.”