Possible Interaction: Albumin and Sphingosine 1-Phosphate

“ S1P bound to albumin exerts both beneficial and harmful effects in the pathogenesis of atherosclerosis, while S1P bound to apoM strengthens anti-atherosclerotic properties and might weaken the pro-atherosclerotic properties of S1P.”

“Importantly, inhibition of paracellular leakage by sphingosine-1-phosphate , which activates Rac and induces cortical actin, caused a significant increase in transcytosis of albumin in vitro and in an ex vivo whole-lung model.”

“Consistent with systemic barrier enhancement, S1P significantly decreased Evans blue dye albumin extravasation and myeloperoxidase content in renal tissues of LPS-treated mice.”

“ S1P produced an approximately 40-50% reduction in LPS-mediated extravasation of Evans blue dye albumin , bronchoalveolar lavage protein content, and lung tissue myeloperoxidase activity (reflecting phagocyte infiltration).”