Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Albumin and Sphingosine 1-Phosphate

supplement:

Albumin

Research Papers that Mention the Interaction

S1P bound to albumin exerts both beneficial and harmful effects in the pathogenesis of atherosclerosis, while S1P bound to apoM strengthens anti-atherosclerotic properties and might weaken the pro-atherosclerotic properties of S1P.
Journal of atherosclerosis and thrombosis  •  2018  |  View Paper
Importantly, inhibition of paracellular leakage by sphingosine-1-phosphate , which activates Rac and induces cortical actin, caused a significant increase in transcytosis of albumin in vitro and in an ex vivo whole-lung model.
The American journal of pathology  •  2012  |  View Paper
Consistent with systemic barrier enhancement, S1P significantly decreased Evans blue dye albumin extravasation and myeloperoxidase content in renal tissues of LPS-treated mice.
S1P produced an approximately 40-50% reduction in LPS-mediated extravasation of Evans blue dye albumin , bronchoalveolar lavage protein content, and lung tissue myeloperoxidase activity (reflecting phagocyte infiltration).
American journal of respiratory and critical care medicine  •  2004  |  View Paper