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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
Research Papers that Mention the Interaction
“In multivariate analysis, albuminemia (p = 0.0036) was the single parameter independently associated with CL.ConclusionThese findings highlight the major influence of albuminemia on sorafenib clearance and its disposition in cancer patients.”
“In physiological conditions, sorafenib unbound fraction would increase 1.7-fold as albuminemia decreased from 45 g/L (680 μM) to 30 g/L (453 μM).”
Functional and Clinical Evidence of the Influence of Sorafenib Binding to Albumin on Sorafenib Disposition in Adult Cancer Patients“ Albumin concentration, the change of pharmacological signal transduction as Raf-B, vascular endothelial growth factor (VEGF), and phosphorylation of MEK1/2 or ERK1/2 were found to be decreased by sorafenib.”
“Our results suggest that particular care should be taken with albuminemia or the combined use of drugs with a high affinity for albumin, such as warfarin, and sorafenib in the treatment of cancer patients.”
“These mechanisms depend on the high binding proper ties of sorafenib and exogenous albumin.”
Exogenous albumin inhibits sorafenib-induced cytotoxicity in human cancer cell lines.“In physiological conditions, sorafenib free fraction would increase 1.7-fold whether albuminemia decreased from 45 g/L to 30 g/L. In presence of bilirubin, apparent Kd of sorafenib was approximately 1.5-fold greater for bilirubin/albumin molar ratio of 1:4.”
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