Possible Interaction: Albumin and Serum Albumin, Human

“HSA(GF) and HSA exhibited an inhibitory effect, with an inhibition constant, Ki, of 19.9 microM (0.13% albumin ) and 42.2 microM (0.35% albumin), respectively.”

“… albumin concentration, changes in the chemical shift values were observed for the aromatic protons H2/H6 (Δσ = 0.013 ppm and 0.018 ppm) and … 0.022 ppm) and the aliphatic protons of the methoxy group H14 (Δσ = 0.019 ppm and 0.022 ppm) for dHSA and HSA, ….”

“We suggest that albumin binding should be taken into careful consideration in antimicrobial peptide studies, as the systemic distribution can be significantly affected by HSA interactions.”

“HSA has many other physiological functions, including the binding and transport of a wide variety of water-insoluble endogenous and exogenous … as in ischemic stroke and Alzheimer’s disease.4,5 It is well known that the oxidation or binding of HSA to … albumin that markedly affect … of HSA.”

“The results showed that the trans-endothelial membrane flux of albumin was significantly increased in a concentration- and time-dependent manner upon the stimulation of AGE-HSA , accompanying with actin reorganization.”

“Thus, the presence of HSA during PMN stimulation not only induced an albumin dose-dependent increase in PAF release but significantly augmented the synthesis of PAF.”

“The following amendments have been introduced to the Minimum Requirements for Human Serum Albumin (HSA) and Plasma Protein Fraction (PPF): 1) The upper limit … required to be stated on the label; 4) use of zone electrophoresis was introduced in addition to the free-boundary electrophoresis; and 5) albumin … HSA …%.”

“Furthermore, when human adipose tissue was incubated in an albumin-containing medium , intracellular cAMP was underestimated by 30 per cent, since albumin increased the binding of camp to the binding protein.”

“Administration of hALB significantly increased (25.0 +/- 1.2 g/l at baseline, 33.4 +/- 1.6 g/l post-infusion, mean +/- SEM, P less than 0.03, n = 5) the circulating albumin concentration.”

“In conclusion, we found for the first time that S-thiolation of albumin is increased in the plasma of HF patients and induced changes in the structure and antioxidant function of HSA , likely contributing to HF progression.”