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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Albumin
drug:
Salicylic Acid
Research Papers that Mention the Interaction
“Carbamoylation of bovine and human albumin in vitro decreased the binding of methyl red and salicylic acid.”
Drug binding defect of uraemic plasma: unlikely involvement of carbamoylated albumin.“ Salicylic acid was shown to displace aspirin from albumin binding sites.”
“There was a statistically significant negative correlation between albumin concentration and the free fraction values of salicylic acid and sulfisoxazole (but not of phenytoin and only under special circumstances with warfarin) in normal subjects and of phenytoin, salicylic acid, and sulfisoxazole (but not warfarin) in rats.”
“Flow microcalorimetry data demonstrated a decrease in the ability of uraemic albumin to bind octanoate, phenol red, salicylic acid , warfarin and diazepam.”
“Displacement of valproic acid (90-95% bound to albumin) and carbamazepine (80% bound to albumin ) by salicylate , leading to higher concentrations of pharmacologically active free drugs, has been reported.”
“Tolbutamide titrations of albumin complexed with three other drugs whose binding sites have been localized by X-ray crystallography ( salicylate , clofibric acid, and triiodobenzoic acid) demonstrated direct competition for common binding sites.”
“Furthermore, a decrease in the affinity of albumin for bilirubin during this period may lead to bilirubin displacement by drugs such as diazepam, sulphonamides and salicylate , resulting in clinical jaundice which would not occur beyond the neonatal period.”
“Chloroquine, propranolol and trifluoperazine were the most potent drugs investigated, inhibiting … binding of adrenergic antagonists at 10(-5)M. Drugs such as salicylate and chlorpropamide, with little affinity for … high capacity for binding to albumin , inhibited lymphocyte transformation at 10(-3)M; …-bound ligands with an affinity for adrenoceptors.”
“It is suggested that the availability of the binding sites for L-tryptophan, warfarin and salicylic acid is partially blocked by the complex between albumin and the dye without direct participation in the complex-formation.”
“ Albumin concentration was positively correlated with the binding of salicylate , but not with binding of the other 4 drugs.”
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