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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Albumin and Propofol



Research Papers that Mention the Interaction

These results indicate that binding to foetal albumin is a determining feature in the control of the placental transfer of propofol , and that the pharmacological effects of propofol on the foetus can be expected to be fairly constant and predictable from the maternal propofol concentration.
propofol were … augmented albumin concentrations in the foetal perfusate (1.68 (SD 0.68), 3.08 (1.55), 4.79 (1.76), 5.75 (1.89) and ….46) ml h-1 g-1 at the albumin concentrations of 4.4, 11, 22, 33 and 44 g litre-1, respectively).
British journal of anaesthesia  •  2000  |  View Paper
This finding can be explained by the fact that propofol binds 97–98% to albumin , which is in much lower concentration in fetal serum during the first half of pregnancy.
The Lancet  •  1998  |  View Paper
The opposite was found for the interaction between propofol and albumin : increase of the binding extent with increasing substrate concentration.
Arzneimittel-Forschung  •  1995  |  View Paper
Increasing the concentration of albumin reduced the inhibitory effect of etomidate and propofol on the [Ca2+]i response to ACh.
Fundamental & clinical pharmacology  •  2000  |  View Paper