Possible Interaction: Albumin and Prednisolone

“Studies in vitro showed that protein binding of prednisolone increased with increasing albumin concentrations, and that bilirubin could displace some bound prednisolone.”

“Secondly, prednisolone is nonlinearly bound to transcortin and albumin : since the unbound concentrations of prednisolone are biologically relevant, it was necessary to determine the free fraction in each plasma sample.”

“The comparison of the affinity constants of prednisone or prednisolone and hydrocortisone for albumin and transcortin demonstrated that prednisolone binds approximately 2Æ5 times stronger to transcortin and more than 300 times stronger to the albumin molecule.”

“As a result of prednisolone binding to both transcortin and albumin , the binding of prednisolone changes as a function of prednisolone concentration.”

“Increase of prednisolone improved the loss of albumin into the bowel and abnormal laboratory findings.”

“ Prednisolone binds in plasma to both albumin and transcortin.”

“ Prednisolone therapy was associated with significant increases in the plasma concentration and synthetic rate of albumin but changes in the intravascular albumin pools were not significant.”

“The use of total Lowry protein concentrations markedly overestimates, while albumin (and transcortin) concentrations severely underestimate the tissue binding of prednisolone.”

“Increasing concentrations of cortisol and prednisolone however caused greater denaturation of albumin.”

“Finally, the dose of PSL (as a continuous variable) was negatively correlated with GA adjusted for age, sex, BMI, Alb , Cre, and A1c.”