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Last Updated: 2 years ago

Possible Interaction: Albumin and Prednisolone

supplement:

Albumin

Research Papers that Mention the Interaction

Studies in vitro showed that protein binding of prednisolone increased with increasing albumin concentrations, and that bilirubin could displace some bound prednisolone.
Journal of clinical gastroenterology  •  1984  |  View Paper
Secondly, prednisolone is nonlinearly bound to transcortin and albumin : since the unbound concentrations of prednisolone are biologically relevant, it was necessary to determine the free fraction in each plasma sample.
Clinical pharmacokinetics  •  1990  |  View Paper
The comparison of the affinity constants of prednisone or prednisolone and hydrocortisone for albumin and transcortin demonstrated that prednisolone binds approximately 2Æ5 times stronger to transcortin and more than 300 times stronger to the albumin molecule.
The British journal of dermatology  •  2004  |  View Paper
As a result of prednisolone binding to both transcortin and albumin , the binding of prednisolone changes as a function of prednisolone concentration.
European Journal of Clinical Pharmacology  •  2004  |  View Paper
Increase of prednisolone improved the loss of albumin into the bowel and abnormal laboratory findings.
Ryumachi. [Rheumatism]  •  1994  |  View Paper
Prednisolone binds in plasma to both albumin and transcortin.
American journal of kidney diseases : the official journal of the National Kidney Foundation  •  1984  |  View Paper
Prednisolone therapy was associated with significant increases in the plasma concentration and synthetic rate of albumin but changes in the intravascular albumin pools were not significant.
The Journal of clinical investigation  •  1970  |  View Paper
The use of total Lowry protein concentrations markedly overestimates, while albumin (and transcortin) concentrations severely underestimate the tissue binding of prednisolone.
Journal of pharmaceutical sciences  •  1984  |  View Paper
Increasing concentrations of cortisol and prednisolone however caused greater denaturation of albumin.
The Journal of pharmacy and pharmacology  •  1970  |  View Paper
Finally, the dose of PSL (as a continuous variable) was negatively correlated with GA adjusted for age, sex, BMI, Alb , Cre, and A1c.
Diabetes Therapy  •  2018  |  View Paper