“In conclusion, our findings provide the first evidence that piperine displaces plasma bound drugs from both albumin and alpha‐acid glycoprotein and facilitates drug uptake across biological membranes (e.g. BMEC).”
“ Piperine (1–1000 μM) increased the free fraction (fu) of both albumin and alpha‐acid glycoprotein bound drugs in a concentration‐dependent manner (p < 0.01).”