Possible Interaction: Albumin and Phenylbutazone

“The red shift in the ultraviolet absorption maximum of phenylbutazone on binding to albumin provided some evidence that the phenyl groups of the drug were located in a region of the protein where the dielectric constant was less than that of water.”

“Similarly PBZ weakens the interaction of ASA with albumin.”

“Aspirin and phenylbutazone inhibited binding of fentanyl to albumin , while quinidine caused inhibition of binding to lipoproteins of all three densities, but not to albumin.”

“Addition of indomethacin, ibuprofen, phenylbutazone and warfarin in concentrations of 10 mg/100 ml displace a significant amount of salicylate bound to albumin.”

“Tolbutamide, indomethacin, sulfamethoxypyridazine, and chlorophenoxyisobutyric acid (CPIB) competitively inhibit the binding of phenylbutazone-14C to albumin.”

“Many acidic drugs phenylbutazone , sulfonamides, coumarin anticoagulants, salicylates, &c.) are highly bound to one or two sites on albumin molecules.”

“P enylbutazone w as found to interfere significantly with the binding of a sulfonamide to al bumin a nd the practical implications of this observation are pointed out.”

“Plasma albumin concentrations decreased significantly from days 10 to 21 during phenylbutazone treatment, compared with results during the same days for the control treatment.”

“ Phenylbutazone and dexamethasone reduced the severity of the inflammatory responses as measured by lower concentrations of albumin and higher pH in treated versus control chamber fluids.”

“ Phenylbutazone-treated horses had a significant (P < 0.05) decrease in serum total protein and albumin concentrations.”