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Last Updated: 2 years ago

Possible Interaction: Albumin and Phenobarbital



Research Papers that Mention the Interaction

…,PB down-regulated expression of transcription factors associated with proliferation such as AP1 and NF-kappaB. In the … PB, hepatocytes remained morphologically differentiated and restoration of the expression of mature hepatocyte markers, such as albumin and cytochrome P450s (1A, 2B1/2, and … accelerated after an initial phase of growth.
Experimental cell research  •  1998  |  View Paper
Exposure to phenobarbital (PB) from Days 1 to 4 dose dependently increased the protein content and decreased the albumin secretion in 13% O2 cultures only.
Toxicology and applied pharmacology  •  1994  |  View Paper
In conditions in which its effect on the … of alpha 1-AGP synthesis was maximum, phenobarbital caused a …% reduction in liver albumin mRNA and in albumin secretion by isolated hepatocytes, resulting from a 60-70% reduction in the rate of transcription of the albumin gene measured in isolated nuclei.
European journal of biochemistry  •  1992  |  View Paper
The intensity of immunohistochemical fluorescence for albumin decreased in both periportal and perivenular hepatocytes from 20-day-old animals treated with PB.
Journal of ultrastructure and molecular structure research  •  1986  |  View Paper
In contrast to these results, the rate of transcription of the serum albumin gene was not affected, and levels of albumin mRNA actually decreased after administration of phenobarbital.
The Journal of biological chemistry  •  1983  |  View Paper
Phenobarbital bound with albumin covalently loses the ability to induce the cytochrome P 450-hydroxylase system but acquires an ability to induce the lymphocytic immunological system.
Biulleten' eksperimental'noi biologii i meditsiny  •  1980  |  View Paper