Possible Interaction: Albumin and Phenobarbital

“…,PB down-regulated expression of transcription factors associated with proliferation such as AP1 and NF-kappaB. In the … PB, hepatocytes remained morphologically differentiated and restoration of the expression of mature hepatocyte markers, such as albumin and cytochrome P450s (1A, 2B1/2, and … accelerated after an initial phase of growth.”

“Exposure to phenobarbital (PB) from Days 1 to 4 dose dependently increased the protein content and decreased the albumin secretion in 13% O2 cultures only.”

“In conditions in which its effect on the … of alpha 1-AGP synthesis was maximum, phenobarbital caused a …% reduction in liver albumin mRNA and in albumin secretion by isolated hepatocytes, resulting from a 60-70% reduction in the rate of transcription of the albumin gene measured in isolated nuclei.”

“The intensity of immunohistochemical fluorescence for albumin decreased in both periportal and perivenular hepatocytes from 20-day-old animals treated with PB.”

“In contrast to these results, the rate of transcription of the serum albumin gene was not affected, and levels of albumin mRNA actually decreased after administration of phenobarbital.”

“ Phenobarbital bound with albumin covalently loses the ability to induce the cytochrome P 450-hydroxylase system but acquires an ability to induce the lymphocytic immunological system.”