Possible Interaction: Albumin and Pentoxifylline

“In renal tubular cells, pentoxifylline prevented the decrease in Klotho expression induced by inflammatory cytokines or albumin.”

“After PTX , the mean albumin significantly increased (3·9 (sd 0·4) g/dl to 4·2 (sd 0·6) g/dl; P<0·05).”

“When used in conjunction with albumin, pentoxifylline protects the kidneys from injury following endotoxemic shock, by decreasing inducible nitric oxide synthase expression in the kidneys [5].”

“However, the combination of albumin and pentoxifylline profoundly protected GFR (148.6 ± 28.7 μl/min, vs. 38.2 ± 18.2 μl/min, p < 0.01) as compared to normal saline.”

“The combined administration of albumin and pentoxifylline significantly attenuated the renal iNOS protein expression and increased cardiac output.”

“We hypothesize that combined administration of albumin with pentoxifylline may protect against the development of AKI during endotoxemic shock in mice by maintaining the integrity of arterial circulation and exerting anti-inflammatory properties.”

“ PX was ineffective in modifying those of A2M and albumin.”

“In conclusion, pentoxifylline attenuates endotoxin-induced increase in albumin clearance across endothelial monolayers both in the presence and absence of neutrophils.”

“ Pentoxifylline significantly attenuated the endotoxin-induced increase in albumin clearance both with and without neutrophils, and lessened endotoxin-induced cell lysis (chromium release) and morphologic changes.”

“ PX was ineffective in modifying those of A2M and albumin.”