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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Palmitate progressively displaces arachidonate from albumin and affects the range of effective arachidonate concentrations but not the maximum response.”
The modulation by serum albumin of rabbit platelet aggregation in response to exogenous sodium arachidonate.“ Palmitate was bound less firmly by human or rabbit albumin than by BSA.”
“The half maximal effective concentrations of oleate and palmitate in the presence of albumin were 5 and 25 microM, respectively.”
“This indicates a much greater affinity of denatured albumin for hexadecanoate since increase in stability derives from the difference between free energy of ligand binding to folded and unfolded protein forms.”
“Whereas palmitate in the presence of albumin revealed a wide range of optimal concentration in supporting maximal enzyme activity, oleate was found to strongly inhibit the reaction.”
“With the addition of palmitate , the free spin label concentration decreases greatly, by almost 80%, in the presence of a fatty acid: albumin ratio of 3:1 to 4:1.”
“ Palmitate elicited cytoskeletal changes in podocytes and increased albumin permeability, which was also blocked by mitoTEMPO.”
Palmitate induces ER calcium depletion and apoptosis in mouse podocytes subsequent to mitochondrial oxidative stress“Here, we show that albumin with fatty acid impurities or conjugated with palmitate but not albumin itself compromised mitochondrial and cell viability, membrane potential and respiration.”
“… palmitate … albumin lowered VFT from 2.19 ± 0.20 mA to 1.56 ± 0.13 mA. The perfusion of 0.36 mM palmitate bound to 0.… 2.05 ± to 0.19 mA to 1.47 ± 0.23 mA, but 0.12 mM FABP alone did not affect the VFT.”
“We used lipid-induced apoptosis as a measure of lipotoxicity and found that 1.5 mM palmitate (6.8:1) bound to albumin resulted in a 15-fold increase in the number of apoptotic cells compared to the control at 24 hours.”
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