Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Albumin and Paclitaxel

supplement:

Albumin

Research Papers that Mention the Interaction

PTX safety was greatly enhanced by embedding with human albumin.
ACS applied materials & interfaces  •  2020  |  View Paper
Furthermore, IBSA induced minimal hepatic and hematologic toxicities compared to IP2K and significantly enhanced the in vivo tumor inhibition activity of paclitaxel albumin nanoparticles when used in combination.
Molecular pharmaceutics  •  2017  |  View Paper
The albumin shields the paclitaxel , increasing its solubility and circulation time and giving it a greater chance of winding up in tumor cells.
Science  •  2010  |  View Paper
Nab-paclitaxel is synthesized by a process of high pressure homogenization of paclitaxel in the presence of human albumin and it was originally developed to reduce the toxicity usually associated with cremophor in soluble paclitaxel and to increase its penetration in tumor tissues.
Bulletin du cancer  •  2015  |  View Paper
Mean FTR of paclitaxel decreased significantly from 5.67 ± 0.02% in low albumin conditions to 1.72 ± 0.09% in physiological albumin conditions.
American journal of obstetrics and gynecology  •  2012  |  View Paper
Results: We found that paclitaxel readily binds to pH-induced partially unfolded albumin , leading to the formation of optically clear water-soluble complexes.
International journal of nanomedicine  •  2011  |  View Paper
Binding of paclitaxel to albumin impact on protein structure and it influences considerably albumin binding of other molecules like warfarin, heme or bilirubin.
Bioorganic & medicinal chemistry  •  2004  |  View Paper
Protein bindings of paclitaxel with the above albumins were more than 40%.
The Journal of toxicological sciences  •  1994  |  View Paper
After 4 hr of incubation, taxol (50 microM) inhibited albumin secretion by only 10% on gestation Day 19, by 16% 4 days after birth, but by 40% in the adult.
Toxicology and applied pharmacology  •  1986  |  View Paper