Possible Interaction: Albumin and Paclitaxel

“ PTX safety was greatly enhanced by embedding with human albumin.”

“Furthermore, IBSA induced minimal hepatic and hematologic toxicities compared to IP2K and significantly enhanced the in vivo tumor inhibition activity of paclitaxel albumin nanoparticles when used in combination.”

“The albumin shields the paclitaxel , increasing its solubility and circulation time and giving it a greater chance of winding up in tumor cells.”

“Nab-paclitaxel is synthesized by a process of high pressure homogenization of paclitaxel in the presence of human albumin and it was originally developed to reduce the toxicity usually associated with cremophor in soluble paclitaxel and to increase its penetration in tumor tissues.”

“Mean FTR of paclitaxel decreased significantly from 5.67 ± 0.02% in low albumin conditions to 1.72 ± 0.09% in physiological albumin conditions.”

“Results: We found that paclitaxel readily binds to pH-induced partially unfolded albumin , leading to the formation of optically clear water-soluble complexes.”

“Binding of paclitaxel to albumin impact on protein structure and it influences considerably albumin binding of other molecules like warfarin, heme or bilirubin.”

“Protein bindings of paclitaxel with the above albumins were more than 40%.”

“After 4 hr of incubation, taxol (50 microM) inhibited albumin secretion by only 10% on gestation Day 19, by 16% 4 days after birth, but by 40% in the adult.”