Possible Interaction: Albumin and Oleic Acid

“We showed that the interaction of OA with albumins isolated from human, bovine, and camel milk results in the formation of complexes with high antitumor activity against Caco-2, HepG-2, PC-3, and MCF-7 tumor cells.”

“Here, we report that extracellular oleic acid complexed with albumin at an unbound concentration of 81 ± 1 nm strongly activated KATP channels and inhibited Kir2.1 channels in Chinese hamster ovary (CHO) cells as well as endogenous Kir currents in human embryonic kidney (HEK293) cells.”

“In conclusion, during brain development the presence of albumin could play an important role by triggering the synthesis and release of oleic acid by astrocytes, thereby inducing neuronal differentiation.”

“Thus, albumin stimulates oleic acid synthesis by astrocytes from the main metabolic substrates available during brain development.”

“In contrast, with IHKE albumin at low concentration abolished the growth inhibiting effect of chlorinated oleic acid and appreciably counteracted growth inhibition by the fatty acid of HepG2.”

“This indicates limitation by the dissociation of oleic acid from albumin and not its translocation across the membrane.”

“It is concluded that albumin undergoes several conformational transitions as the amount of oleic acid bound increases from 0 to about 9 molecules/molecule of protein.”

“… albumin, oleic acid significantly inhibited the cAMP accumulation of plasma membrane activated by thyrotropin at 2.4 mmol/l (P less than 0.01 when the … and pH was 7.4; P less than 0.001 when the albumin concentration was 20 g/l and pH was 7.2).”

“At molar ratios of oleic acid to albumin in excess of 4.25 at pH6, 3.1 at pH7.4 and 2.4 at pH9 cause a decrease in aflatoxin B1 fluorescence as a result of reduced binding to albumin.”

“The data suggest that the serum concentrations of albumin and other T4-binding proteins are important in modulating the DFT4-increasing effect of oleic acid and that oleic acid may contribute to the reduced serum binding of T4 in nonthyroidal illness.”

“Addition of oleic acid at a 3:1 molar ratio with albumin significantly increased the binding of warfarin and DNSA to site I.”