Possible Interaction: Albumin and Octanoate

“Flow microcalorimetry data demonstrated a decrease in the ability of uraemic albumin to bind octanoate , phenol red, salicylic acid, warfarin and diazepam.”

“The presence … mol of octanoate or decanoate … mol of albumin caused a decrease in dye binding (dye/protein molar ratio 1:1), which, in contrast with additional fatty acid, was … pronounced: 1-8 mol of palmitate or stearate resulted in a small, and apparently linear, displacement of Phenol Red.”

“However, the oxidation of the medium chain fatty acid octanoate was inhibited in the presence of albumin over a broad range of octanoate concentrations (0.5-5.0 mM).”

“At physiological albumin concentrations, the intracellular concentration of octanoate is only 7% of the extracellular concentration.”

“Hepatic ketogenesis was similar at 37 degrees with albumin , palmitate, or acetate, but was stimulated significantly by octanoate at 37 degrees and 42 degrees C. At 42 degrees, ketone formation increased in the presence of palmitate.”