Possible Interaction: Albumin and Naproxen

“Non-steroidal … and naproxen … albumin at low concentrations (EC50 10−4–10−5 mol/l) comparable to those active in a classical turbidimetric method, whereas the effect … and formic, fumaric, maleic, malonic, and succinic acid (EC50 10−1–10−2 mol/l in the Mizushima test) was not detectable.”

“Other widely used nonsteroidal antiinflammatory drugs like tolmetin, ibuprofen, and naproxen are also strongly bound to albumin and can potentially displace phenytoin.”

“All three reactions are inhibited by compounds such as naproxen and decanoic acid which are known to also inhibit the acylation of albumin by reactive esters and the reversible binding of benzodiazepines.”

“Our findings support the notion that high binding to LB reduces the biotransformation of BPA and N AP when administered alone or in mixtures in the IPRL system.”

“The addition of LB significantly influenced the liver kinetics of BPA and N AP either administered alone or in binary mixtures, which was reflected in the Michaelis-Menten constants.”

“Adiabatic compressibility measurements revealed that NS caused unfolding of EA , an effect which led to a decrease in EA intrinsic compressibility and the exposure of atomic side groups buried in protein interior.”

“In concentrated EA solutions, the results showed a large increase in EA compressibility and ultrasonic absorption in the presence of NS indicating a strong aggregation of the denatured state of EA.”

“Using EPR … that incorporating NS into EA matrix strongly influences the microstructure of the protein gel, and hence the transport of the penetrant within the matrix, compared … presence of NS increased the protein chain mobility and hydration which supports our previous results showing that NS cause unfolding of EA.”

“The skew is shown to be due to strong binding of naproxen to albumin present in the blood plasma.”