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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Albumin and Methotrexate



Research Papers that Mention the Interaction

Drugs used in combination with MTX in therapy (vincristine, vinblastine, cyclophosphamide, 5-fluorouracil, prednisone) depress the MTX binding to albumins.
MTX binds to two kinds of albumins binding sites, with different binding constants: K1 = 8.88 mM-1 and K2 = 1.76 mM-1.
Polish journal of pharmacology and pharmacy  •  1990  |  View Paper
The considerable discrepancy in the molecular weight of MTX (454 Da) and albumin (about 67,000 Da) tempted researchers to load multiple drug molecules on one carrier molecule.
Anti-cancer drugs  •  1997  |  View Paper
Increased MTX concentration were paralleled by significantly increased albumin concentrations in the CSF.
Klinische Padiatrie  •  1987  |  View Paper
MTX induced significant increase in circulating liver function marker enzymes and bilirubin with concomitant declined albumin levels.
Chemico-biological interactions  •  2017  |  View Paper
Taken together, the pharmacokinetics and liver targetability of MTX could be favorably modulated by controlling the lactose content on the albumin conjugates.
Drug delivery  •  2001  |  View Paper
In addition the conjugation to albumin might enhance the therapeutic effects over those achieved by long-term continuous infusion of MTX , as MTX(1)-RSA enters the cells by a different uptake mechanism.
Anti-cancer drugs  •  1997  |  View Paper
The presence of albumin in the buffer markedly reduces bromosulfophthalein inhibition of MTX influx, but has a much lesser effect on taurocholate inhibition of methotrexate influx, presumably related to the much higher affinity of albumin for bromosulfophthalein than for taurocholate.
Cancer research  •  1980  |  View Paper