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“Concentrations of 0.8 mM morphine and heroin, 0.4 mM meperidine, and 0.005 mM methadone inhibited the albumin synthesis by about 50% after 24 h of pretreatment.”
“The curves were similar for codeine and morphine, while the methadone curve indicated less of a decrease in nK with an increasing albumin concentration.”
Journal of pharmaceutical sciences • 1980 | View Paper
“The inhibitory effect of naloxone, methadone , or naloxone plus methadone on albumin accumulation in the culture medium was greater than the drug-induced reduction of protein synthesis.”