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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Albumin
drug:
Leukotriene B4
Research Papers that Mention the Interaction
“Reduction of albumin in the buffer to 0.5% increased the apparent potencies of LTB4 and 6-cis-LTB1 five-fold.”
Influence of standard and novel LTB4 analogs on human neutrophil chemotaxis measured by the multiwell cap assay.“ Albumin , at concentration normally present in plasma (approximately 600 microM), significantly inhibited leukotriene B4 formation induced by a receptor mediated (fMet-Leu-Phe) and a receptor independent (calcium ionophore A23187) stimuli in human neutrophils.”
“ LTB4 release was increased in the presence of albumin , but was not affected by extracellular calcium or A23187.”
“It is suggested that binding of LTB4 to albumin in vivo will in part determine the available concentration of LTB4 in inflammatory lesions.”
“ LTB4 and LTD4, 5-LO products, decreased the uptake of albumin in LLC-PK1 cells, a well-characterized porcine PT cell line.”
5-Lypoxygenase Products Are Involved in Renal Tubulointerstitial Injury Induced by Albumin Overload in Proximal Tubules in Mice“Protection at higher protein-concentration may be the result of LTB4 binding to albumin.”
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