Possible Interaction: Albumin and Leucine

“… L … albumin leakage than 20 L with both filters, though only with the FX 1000 FMC was it significant (minimum albumin leakage during first hour with …] mg; with PF 210 Gambro 20 L: 869.1 [420.0–3214.7] mg; 30 L: 1841.7 [443.8–3417.5] mg).”

“The addition of leucine , but not of valine or isoleucine, to AA-free medium increased albumin secretion and stimulated the nuclear import of PTB.”

“These data indicate that the mammalian target of rapamycin is involved in the regulation of PTB localization and that leucine promotes albumin synthesis by inhibiting the formation of the albumin mRNA-PTB complex.”

“Finally, we demonstrate that the leucine zipper of C/EBP alpha participates in determining the cell type specificity of albumin promoter activation, as it exerts a strong negative effect on albumin promoter activation in the nonhepatic HeLa cell line but not in HepG2 cells.”

“In nonsurvivors threonine, valine, leucine , phenylalanine, lysine, and histidine all rose significantly (p less than or equal to 0.025) with albumin infusion.”

“ L is equally sensitive towards Hg(2+) in the presence of albumin proteins and in blood serum and milk.”

“ L , with or without MT, increased theta for Ficoll(55-80A) and albumin rapidly and markedly.”

“A decrease in plasma albumin concentration (P < 0.05) was observed with L in MAA and with C in RVA and MAA.”

“Deprivation of … cells for leucine or tryptophan causes approximately …-45% decrease in albumin gene transcription; however, this effect does not account for the 15-17-fold decrease in albumin mRNA abundancy … by tryptophan limitation, or the greater effect of tryptophan limitation as compared to leucine limitation on albumin mRNA.”

“Smooth microsomes contained higher levels of albumin than rough microsomes, but after short times of labeling with [3H]leucine the specific activity of albumin in the latter was higher, supporting the notion that newly synthesized serum proteins are transferred from rough to smooth portions of the ER.”

“At physiological concentrations albumin inhibits leucine incorporation in normal tissues and hepatoma cells, but at lower concentrations the response can differ.”

“In the absence of Ca 2+ and Mg 2+ albumin depresses leucine incorporation in liver but stimulates it in hepatoma cells.”