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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Albumin
drug:
Interferons
Research Papers that Mention the Interaction
“Recoveries increased from 2- to 8-fold if interferon was injected in 4% albumin or with hyaluronidase, respectively.”
The lymphatic route. 1) Albumin and hyaluronidase modify the normal distribution of interferon in lymph and plasma“On the other hand, addition of ALB improved IFN absorption through the lymphatics after s.c.”
“When albumin is defatted prior to immobilization, its interaction with interferon becomes stronger, suggesting that hydrophobic binding is a major force in complex formation.”
“The increase of ALB concentration (from 4 to 10%) caused a significant reduction of the plasma IFN Cmax while both the mean residence time and the release time of IFN increased linearly with the ALB concentration.”
The lymphatic route--II. Pharmacokinetics of human recombinant interferon-alpha 2 injected with albumin as a retarder in rabbits.“TNF-α (12.5 U/ml) treatment did not change albumin permeability, but in combination with IFN-γ (20 U/ml), there was a marked increase in the number of sites of extravascular albumin in postcapillary venules.”
Cadherin-5 redistribution at sites of TNF-α and IFN-γ-induced permeability in mesenteric venules.
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