supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Albumin
drug:
Insulin Detemir
Research Papers that Mention the Interaction
“The effects of Det and Deg, but not insulin and Gla were suppressed by addition of albumin.”
Different impacts of acylated and non-acylated long-acting insulin analogs on neural functions in vitro and in vivo.“Because of the binding of detemir to albumin with high affinity, the phosphorylation kinetics and glucose uptake of detemir, but not glargine, decreased with increasing concentrations of BSA.”
“The protracted action of insulin detemir is explained by increased self-association and reversible binding to albumin , which slows its systemic absorption from the injection site.”
“Aims/hypothesisThe association of insulin detemir with non-esterified fatty acid binding sites on albumin may limit its transfer from the circulation into the extravascular extracellular space in adipose tissue and muscle, due to the capillary endothelial cell barrier.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback