Possible Interaction: Albumin and Indomethacin

“ Indomethacin treatment induced a significant reduction in urinary prostaglandin E2 excretion (73%, p<0.01), glomerular filtration rate diminished from 120±18 to 106±….73m2 (p<0.05), albuminuria declined from 148 to 69 μg/min (median and range) (p<0.05) and fractional clearance of albumin diminished ….05).”

“In patients given irbesartan, the addition of indomethacin further reduced proteinuria and fractional clearance of albumin.”

“ Indomethacin treatment induced a significant reduction in urinary prostaglandin E2 excretion (73%) (2p<0.01), urinary albumin excretion rate diminished from 207 (63–253) to 87 (49–147) mg/24 h (2p<0.01), fractional clearance of albumin declined (70%) (2p<0.01).”

“Pretreatment with indomethacin significantly reduced albumin extravasation after the administration of adrenaline but not after bicuculline, i.e. when acute hypertension was combined with a metabolically mediated cerebral vasodilatation.”

“In comparing protein binding, acemetacin, like indometacin , is found to bind strongly to albumin.”

“From these results we conclude that indomethacin induces displacement of bilirubin from albumin , thus increases bilirubin binding to human erythrocytes to a significant degree even at lower concentrations.”

“We have also demonstrated that this effect ofindomethacin is highly dependent on the presence of albumin in the incubation medium.”

“Addition of indomethacin , ibuprofen, phenylbutazone and warfarin in concentrations of 10 mg/100 ml displace a significant amount of salicylate bound to albumin.”

“Disruption as measured with albumin and 14C-sucrose, but not TEER, was blocked by indomethacin.”

“L-NAME and IND alone at the dose employed significantly reduced the exudate volume and albumin levels by 21-26%.”