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“Incubation of … cells with ICG … albumin production (98.9 ± 0.02 ng/mL, 66.6 ± 0.05 ng/mL and 39.1 ± 0.4 ng/mL for control …, and 0.5mg/mL and 1.0mg/mL ICG, respectively), and decreased [(3)H]-thymidine incorporation in a dose-dependent manner.”
“In cirrhotic livers, a correlation was found between the hepatic extraction of indocyanine green (ICG) and the extravascular space accessible to albumin (r = .84, P < .05), suggesting that the impaired access of this protein‐bound dye to the hepatocyte surface contributed to its impaired elimination.”
“In parallel with this, the hepatic extraction of indocyanine green decreased and was correlated with the albumin space (r = 0.821, P less than 0.001).”
The Journal of clinical investigation • 1982 | View Paper
“The study confirms that the binding of ICG with the bind sits on the albumin will result in improved hydrolytic stability and high photoluminescence quantum yield (PLQY).”