Possible Interaction: Albumin and Ibuprofen

“ Ibuprofen significantly inhibited diclofenac binding to site II of albumin in mimic aqueous humor, but not in pooled aqueous humor.”

“ Ibuprofen (14 mg/kg) intravenously administered 15 min prior to albumin , blunted all the above responses.”

“Indeed, ibuprofen displaces bilirubin from albumin binding site at high concentrations in vitro.”

“They were found to have similar effectiveness, but ibuprofen-treated infants experience lower serum creatinine values, higher urine output, … less undesirable decreased organ blood flow than indomethacin-treated patients, although some authors raised the question of risk that ibuprofen displaces … from albumin and increases its toxicity in preterm infants.”

“Non-…, ibuprofen and … albumin at low concentrations (EC50 10−4–10−5 mol/l) comparable to those active in a classical turbidimetric method, whereas the effect of … and formic, fumaric, maleic, malonic, and succinic acid (EC50 10−1–10−2 mol/l in the Mizushima test) was not detectable.”

“High concentrations of acetylsalicylic acid and ibuprofen decrease the affinity of NN304 for albumin , but these interactions occur at drug-to-albumin concentration ratios that are higher than clinically relevant.”

“Other widely used nonsteroidal antiinflammatory drugs like tolmetin, ibuprofen , and naproxen are also strongly bound to albumin and can potentially displace phenytoin.”

“Acetylsalicylic acid induced an increase in cholesterol, triglyceride, and iron; albumin , uric acid, and creatinine decreased with ibuprofen therapy.”

“Addition of indomethacin, ibuprofen , phenylbutazone and warfarin in concentrations of 10 mg/100 ml displace a significant amount of salicylate bound to albumin.”

“ Ibuprofen is known to interfere with bilirubin– albumin binding.”