Possible Interaction: Albumin and Hydrogen Peroxide

“ Albumin also decreased H2O2 concentrations in vitro.”

“A kinetic analysis suggested that binding to Hx or Alb inhibited the primary activation of heme by H2O2 , the step common for both peroxidase- and catalaselike activities of hemin.”

“ Control albumin treated with t-BOOH and H2O2 showed an increase in the mobility of 16-DS.”

“In contrast, coating with albumin reduced H2O2 without effecting cytochromec reduction.”

“In preliminary experiments, pre-exposure of either albumin or glomerular basement membrane to neutrophil myeloperoxidase with H2O2 and chloride increased their susceptibility to proteolysis 2-3-fold.”

“ Albumin or human platelet-poor plasma inhibited the platelet activation by hydrogen peroxide and methyl-Hg and suppressed the potentiation by dazoxiben.”

“Literature findings report a synergistic effect of the combination of the abundant protein albumin and hydrogen peroxide (H2O2) on the extent of metal release and corrosion of Ti6Al4V.”

“…,H2O2 increased the permeability of … layer of podocytes to albumin : Transmembrane flux for albumin increased five‐fold (106.6 ± 5.2 µg/ml vs. 20.2 ± 2.5 µg/ml, P < 0.05, n = 5), and the PKG inhibitor Rp‐8‐Br‐cGMPS (100 µM) prevented the flux increase.”

“Likewise, nuclear translocation of albumin is induced by exposure of cells to hydrogen peroxide or a phorbol ester, indicating a functional linkage between reactive oxygen species, calcium, and PKC-signaling pathways.”

“PAEC barrier function, measured as the transmonolayer clearance of albumin , was significantly impaired by H2O2 (10-100 microM) in the absence of cytotoxicity.”