Possible Interaction: Albumin and Homocysteine

“The mean change from baseline in homocysteine concentration by both treatments compared with placebo (ET, -13%; EPT, -10%) was accompanied by a decrease in the concentration of vitamin B6 (ET, -25%; EPT, -38%) and albumin (ET, -7%; EPT, -11%).”

“ Homocysteine correlated negatively with levels of vitamins B6, B12, and folate and positively with Q Albumin.”

“Recently, it has been observed that Hcys and HTL may modify plasma proteins, including albumin , hemoglobin or fibrinogen, but the role of this process is not yet well known.”

“We now extend these studies to show that human albumin , but not ceruloplasmin, mediates the conversion of homocysteine to its low molecular weight disulfide forms (homocystine and homocysteine-cysteine mixed disulfide) by thiol/disulfide exchange reactions.”

“In conclusion, increases in fasting homocysteine in diabetic patients are associated with increased albumin excretion rate, especially in those with NIDDM, thus providing a potential new link between microalbuminuria, diabetic nephropathy and cardiovascular disease. [”

“Analysis of covariance including age, gender, folate concentrations, vitamin B12 levels, albumin and creatinine as covariables revealed a significant influence of the (+/+) genotype, albumin and folate status on tHcy levels in hemodialysis patients.”

“Most of the Hcy in plasma covalently binds to the cysteine residues of albumin by disulfide bonds.”

“Altogether, we highlight a mechanism that FA reduces the plasma Hcy level and thereby enhance the bilirubin-binding ability of albumin , which may provide a novel therapeutic strategy for the treatment of pathological neonatal jaundice.”