Possible Interaction: Albumin and Heparin

“Therefore, we prepared albumins with clusters of negatively charged groups by coupling of heparin.”

“While only a small percentage of albumin molecules underwent fragmentation in the presence of heparin with glucose, albumin turned out to display in an even higher proportion structural modifications consistent with a higher degree of ordered structure.”

“Addition of human albumin to fresh plasma collected into CPDA-1, citrate, or heparin (4 U/ml) resulted in an average of 2.8 fold (+/- 0.34 SD, n = 17) increase in yields of Cr fibrinogen.”

“Monochromatic measurement of albumin by the bromcresol green method leads to overestimation of albumin in the presence of heparin.”

“Catheters coated with a conjugate of heparin and albumin showed a four- to five-fold reduction in platelet adhesion as compared to uncoated catheters.”

“ Heparin can displace drugs from albumin by increasing free fatty acid concentrations, but this appears to be an in vitro artefact.”

“Activation of protein kinase C, as well as an increase in intracellular cAMP, abolished this increase in albumin expression in the presence of heparin.”

“Soluble heparin enhanced albumin expression in hepatocytes.”

“We conclude that heparin induces albumin expression in hepatocytes and activation of protein kinase C or increased intracellular cAMP antagonize this effect.”

“Rabbit albumin enhanced the effect of heparin on the LPL activity, while heterologous protein, to the contrary, diminished it.”

“The amount of the adsorption of albumin and fibrinogen decreased with increasing graft amount and heparin content.”