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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“It is assumed that halothane causes reversible conformational changes of the albumin molecule resulting in altered binding characteristics for thiopental.”
pH-dependent interaction of halothane upon thiopental binding to human serum albumin.“Haemoglobin, albumin , red cell membranes and triglycerides were found to contribute significantly to the solubility, and thus the transport, of halothane in whole blood.”
“ Halothane in a concentration of 15 mg/100 ml caused a small but significant increase in dye-binding by 4 g/100 ml human albumin solutions.”
“Protection factors for slowly exchanging albumin hydrogens are increased in a concentration-dependent manner by up to 27-fold with 10 mM halothane , whereas more rapidly exchanging groups of albumin hydrogens have either unaltered or decreased protection factors.”
Differential halothane binding and effects on serum albumin and myoglobin.“ Halothane (1.3 MAC) and ethanol (0.4%) depress albumin synthesis in isolated perfused rat livers (IPRLs).”
“Subsequent exposure to halothane produced a 10x increase in anti-trifluoro acetylated albumin antibody response compared to controls, as well as centrilobular lesions consistent with halothane toxicity.”
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