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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“In contrast, glibenclamide inhibition of recombinant KATP channels was dramatically suppressed by albumin (predicted free drug concentration <0.1%).”
Binding of sulphonylureas to plasma proteins – A KATP channel perspective“The differences between the IDDM and NIDDM group probably occurred because 6 NIDDM patients were taking glibenclamide (7.0-10.5 mg/day) which is known to inhibit the glycosylation reaction of albumin.”
“Irradiation of [3H]glibenclamide at 254 or 300 nm in the presence of albumin resulted in covalent labeling of the albumin molecule.”
Direct photoaffinity labeling of the putative sulfonylurea receptor in rat β‐cell tumor membranes by [3H]glibenclamide“Addition of glibenclamide decreased internal pH (pHin), and addition of albumin reversed this drop by 50%.”
Sulfonylureas rapidly cross phospholipid bilayer membranes by a free-diffusion mechanism.
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