Possible Interaction: Albumin and Ethanol

“These results demonstrate that a moderate dose of alcohol (28 g, approximately 2 drinks) slightly affects postprandial hepatic protein metabolism by blunting the meal-induced increase in albumin synthesis, whereas it does not interfere with fibrinogen synthesis as do higher doses.”

“This loss of mitochondrial membrane potential caused by allyl alcohol preceded inhibition of albumin and urea biosynthesis.”

“… albumin … ethanol , reached a maximum mean ethanol concentration at 20 h (217.3 ± 23.5 mg dl−1), decreased significantly at 30 h to 175.4 ± … dl−1 at 40 h. Ethanol concentrations in the albumin were comparable to human blood alcohol levels during intoxication ( > 150 mg dl−1).”

“Both acute and chronic ethanol administration inhibit the secretion of albumin and glycoproteins from the liver.”

“Prior chronic exposure to ethanol (5 g/kg/day for 6 weeks) potentiated the inhibition of synthesis of all protein fractions (including albumin ) up to about 50%.”

“Plasma survivals of reprocessed and heat‐ethanol produced albumins were significantly less than that of the native protein (0.02”

“ Ethanol was shown to interfere with albumin synthesis and the effect was shown to differ when livers from fed and fasted animals were compared.”

“Analysis of the temperature dependences of the denaturation enthalpy of three domains of albumin molecule showed significant distinctions in the destabilizing effect of ethanol on certain domains of the nondefatted and defatted albumin molecules.”

“The relatively larger jejunal losses of albumin suggest that ethanol induces increased microvascular permeability of the jejunum as well.”

“This ethanol challenge induced within 20-30 minutes a 10-fold increase in albumin (P less than 0.001) and a two-fold increase in the glycosaminoglycan hyaluronic acid (P less than 0.05) in the perfusion fluid.”

“The data showed that the albumin fractions obtained from ethanol-containing macrophage cultures were considerably more cytotoxic than those obtained from ethanol-containing cultures of PLC/PRF/5 and Hep G2 cells.”