Possible Interaction: Albumin and Estradiol

“The production of albumin in osteoblastic cells was significantly enhanced in the presence of PTH, IGF-I, 17beta-estradiol or zinc sulfate.”

“It was found that estradiol binds to the globulin and albumin in a nonlinear manner: a lag period of binding was observed at low concentrations of the proteins, followed by an exponential increase of the bound hormone as the protein concentration increased.”

“These effects of AGE‐albumin are largely prevented by 17β‐oestradiol.”

“Progesterone and estradiol conjugated to albumin , also produced a rapid increase in [Ca2+]i, which was prevented by Ca2+ removal from the medium or when SKF-96365 or U-73122 were added.”

“Moreover, albumin has an effect on the level of radioactivity incorporated when the cells are incubated with radioactive estradiol , and it is necessary to observe the mitogenic effect of estradiol towards the MCF-7 cells.”

“Indeed, treatment of hepatocytes with 1 microM estradiol led, after 24 h, to a dramatic decrease in Alb mRNA level.”

“ Albumin and SHBG decreased beta-galactosidase activity in the presence of estradiol to a greater extent than DES, o,p'-DDT, and OP.”

“This notion received further support in that significant potentiation of the NE-induced pressor response was also observed with estradiol 17β conjugated to albumin (700 nM), but not when electrical field stimulation was used.”

“However, only estradiol treatments significantly elevated albumin levels in the uterine fluid of the immature mice while the highest methoxychlor doses significantly increased the uterine cell heights when compared to all other groups.”

“The addition of 4% albumin to the injection solution led to significant inhibitions of extraction of estradiol (E2) and estrone sulphate (E1-S) only.”