Possible Interaction: Albumin and Doxorubicin Hydrochloride

“Besides, the in vivo fluorescence imaging study confirmed that the peptide markedly increased the payload accumulation in tumor tissues and indicated that albumin binding domain fusing tumor-specific sequence effectively enhanced the tumor delivery of doxorubicin and thus improved its therapeutic potency.”

“When he began his work on transferrin-mediated drug delivery in 1989 to test the efficacy of acid-sensitive transferrin doxorubicin conjugates, he used albumin as a negative control.”

“BACKGROUND The conjugate of doxorubicin with lactosaminated human albumin has the potential of increasing the doxorubicin efficacy in the treatment of hepatocellular carcinomas expressing the asialoglycoprotein receptor.”

“In cancer patients the fraction of free adriamycin decreased with increasing plasma albumin concentration.”

“The inverse correlation of activity and conjugation … demonstrates a low cytotoxic activity of DOX in acid-stable binding to monomeric albumin , pointing to a selective cytostatic activity of the modified albumin against ES and PNET cells, even in the presence of a 100 fold excess of unmodified serum albumin.”

“ Doxorubicin caused a reduction in HDL and albumin levels (p < 0.01) as well as superoxide dismutase, glutathione peroxidase and catalase activities (p < 0.05) with a concomitant increase in liver malondialdehyde (p < 0.05) and liver damage (p < 0.001).”

“Treatment with adriamycin led to a significant increase in the fractional clearance of albumin and of Ficoll with radii larger than 20 A. Neutral albumin (33.4 A) and similarly sized Ficoll behaved similarly to each other.”

“Indeed, we found that the permeability of monolayers of bovine pulmonary artery endothelial cells (BPAEC) to albumin was increased by approximately 10-fold above control, following 24-h exposure to clinically relevant concentrations of DOX (up to 1 microM).”

“ ADR caused a significant increase in FFA, decrease in albumin , and an increase in FFA/albumin.”

“This specific association between albumin and doxorubicin derivative is accompanied by large changes in the spectral characteristics of the anthracycline chromophore.”